Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial
Identifieur interne : 001249 ( Main/Exploration ); précédent : 001248; suivant : 001250Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial
Auteurs : Juergen Fischer [Allemagne] ; Uwe Dethlefsen [Allemagne]Source :
- Cough (London, England) [ 1745-9974 ] ; 2013.
Abstract
Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.
As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.
After 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.
The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.
ISRCTN:
Url:
DOI: 10.1186/1745-9974-9-25
PubMed: 24261680
PubMed Central: 3842692
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000661
- to stream Pmc, to step Curation: 000661
- to stream Pmc, to step Checkpoint: 000703
- to stream Ncbi, to step Merge: 000413
- to stream Ncbi, to step Curation: 000413
- to stream Ncbi, to step Checkpoint: 000413
- to stream Main, to step Merge: 001251
- to stream Main, to step Curation: 001249
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial</title>
<author><name sortKey="Fischer, Juergen" sort="Fischer, Juergen" uniqKey="Fischer J" first="Juergen" last="Fischer">Juergen Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Norderney Hospital, Kaiserstr. 26, Norderney D-26548, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Norderney Hospital, Kaiserstr. 26, Norderney D-26548</wicri:regionArea>
<wicri:noRegion>26548</wicri:noRegion>
<wicri:noRegion>26548</wicri:noRegion>
<wicri:noRegion>Norderney D-26548</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dethlefsen, Uwe" sort="Dethlefsen, Uwe" uniqKey="Dethlefsen U" first="Uwe" last="Dethlefsen">Uwe Dethlefsen</name>
<affiliation wicri:level="3"><nlm:aff id="I2">MKL Institute of Clinical Research, Pauwelsstr. 17, Aachen D-52074, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>MKL Institute of Clinical Research, Pauwelsstr. 17, Aachen D-52074</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24261680</idno>
<idno type="pmc">3842692</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842692</idno>
<idno type="RBID">PMC:3842692</idno>
<idno type="doi">10.1186/1745-9974-9-25</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000661</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000661</idno>
<idno type="wicri:Area/Pmc/Curation">000661</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000661</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000703</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000703</idno>
<idno type="wicri:Area/Ncbi/Merge">000413</idno>
<idno type="wicri:Area/Ncbi/Curation">000413</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000413</idno>
<idno type="wicri:Area/Main/Merge">001251</idno>
<idno type="wicri:Area/Main/Curation">001249</idno>
<idno type="wicri:Area/Main/Exploration">001249</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial</title>
<author><name sortKey="Fischer, Juergen" sort="Fischer, Juergen" uniqKey="Fischer J" first="Juergen" last="Fischer">Juergen Fischer</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Norderney Hospital, Kaiserstr. 26, Norderney D-26548, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Norderney Hospital, Kaiserstr. 26, Norderney D-26548</wicri:regionArea>
<wicri:noRegion>26548</wicri:noRegion>
<wicri:noRegion>26548</wicri:noRegion>
<wicri:noRegion>Norderney D-26548</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dethlefsen, Uwe" sort="Dethlefsen, Uwe" uniqKey="Dethlefsen U" first="Uwe" last="Dethlefsen">Uwe Dethlefsen</name>
<affiliation wicri:level="3"><nlm:aff id="I2">MKL Institute of Clinical Research, Pauwelsstr. 17, Aachen D-52074, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>MKL Institute of Clinical Research, Pauwelsstr. 17, Aachen D-52074</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Aix-la-Chapelle</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cough (London, England)</title>
<idno type="eISSN">1745-9974</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objective</title>
<p>Cineole has mucolytic, bronchodilating and anti-inflammatory properties and reduces the exacerbation rate in patients suffering from COPD, as well as ameliorates symptoms in patients suffering from asthma and rhinosinusitis. Based on these effects, we therefore postulated the hypothesis that patients with acute bronchitis would also benefit from therapy with Cineole.</p>
</sec>
<sec><title>Methods</title>
<p>As part of a double-blind, placebo-controlled, multi-center-study, a total of 242 patients with confirmed acute bronchitis was randomly selected to participate. Over a period of 10 days, all patients were administered 3 x 200 mg of Cineole, or a respective placebo, per day. The primary outcome measure was a Bronchitis Sum Score, which summarises the relevant symptoms of acute bronchitis.</p>
</sec>
<sec><title>Results</title>
<p>After 4 days of treatment it was notable, that the patient group treated with Cineole, showed significantly more improvements of the bronchitis-sum-score than those of the placebo group (p = 0.0383). The statistical significant difference of the individual outcome measures was especially underlined by the frequency of cough fits by p = 0.0001 after 4 days.</p>
</sec>
<sec><title>Conclusions</title>
<p>The effects of Cineole in the treatment of acute bronchitis were clearly measurable and could be proven after a treatment period of merely 4 days. This study corroborates the fact that Cineole actively and significantly reduces cough frequency after four days. Therefore it has been shown to have a great socioeconomic impact.</p>
</sec>
<sec><title>Trial registration</title>
<p>ISRCTN: <ext-link ext-link-type="uri" xlink:href="http://www.copntrolled-trials.com.com/ISRCTN37784439">ISRCTN37784439</ext-link>
</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Braman, S" uniqKey="Braman S">S Braman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonzales, R" uniqKey="Gonzales R">R Gonzales</name>
</author>
<author><name sortKey="Bartlett, Jg" uniqKey="Bartlett J">JG Bartlett</name>
</author>
<author><name sortKey="Besser, Re" uniqKey="Besser R">RE Besser</name>
</author>
<author><name sortKey="Cooper, Rj" uniqKey="Cooper R">RJ Cooper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonzales, R" uniqKey="Gonzales R">R Gonzales</name>
</author>
<author><name sortKey="Sande, Ma" uniqKey="Sande M">MA Sande</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hopstaken, Rm" uniqKey="Hopstaken R">RM Hopstaken</name>
</author>
<author><name sortKey="Coenen, S" uniqKey="Coenen S">S Coenen</name>
</author>
<author><name sortKey="Butler, Cc" uniqKey="Butler C">CC Butler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Linder, Ja" uniqKey="Linder J">JA Linder</name>
</author>
<author><name sortKey="Sim, I" uniqKey="Sim I">I Sim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Macfarlane, J" uniqKey="Macfarlane J">J MacFarlane</name>
</author>
<author><name sortKey="Holmes, W" uniqKey="Holmes W">W Holmes</name>
</author>
<author><name sortKey="Gard, P" uniqKey="Gard P">P Gard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wenzel, Rp" uniqKey="Wenzel R">RP Wenzel</name>
</author>
<author><name sortKey="Fowler, Aa" uniqKey="Fowler A">AA Fowler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kehrl, W" uniqKey="Kehrl W">W Kehrl</name>
</author>
<author><name sortKey="Sonnemann, U" uniqKey="Sonnemann U">U Sonnemann</name>
</author>
<author><name sortKey="Dethlefsen, U" uniqKey="Dethlefsen U">U Dethlefsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Worth, H" uniqKey="Worth H">H Worth</name>
</author>
<author><name sortKey="Schacher, C" uniqKey="Schacher C">C Schacher</name>
</author>
<author><name sortKey="Dethlefsen, U" uniqKey="Dethlefsen U">U Dethlefsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Worth, H" uniqKey="Worth H">H Worth</name>
</author>
<author><name sortKey="Dethlefsen, U" uniqKey="Dethlefsen U">U Dethlefsen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fahy, Jv" uniqKey="Fahy J">JV Fahy</name>
</author>
<author><name sortKey="Dickey, Bf" uniqKey="Dickey B">BF Dickey</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>District de Cologne</li>
<li>Rhénanie-du-Nord-Westphalie</li>
</region>
<settlement><li>Aix-la-Chapelle</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Fischer, Juergen" sort="Fischer, Juergen" uniqKey="Fischer J" first="Juergen" last="Fischer">Juergen Fischer</name>
</noRegion>
<name sortKey="Dethlefsen, Uwe" sort="Dethlefsen, Uwe" uniqKey="Dethlefsen U" first="Uwe" last="Dethlefsen">Uwe Dethlefsen</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001249 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001249 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= CovidV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:3842692 |texte= Efficacy of cineole in patients suffering from acute bronchitis: a placebo-controlled double-blind trial }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24261680" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a CovidV2
This area was generated with Dilib version V0.6.33. |